LOXIGLUMIDE
Synonym(s):4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-pentanoic acid;CR 1505
- CAS NO.：107097-80-3
- Empirical Formula: C21H30Cl2N2O5
- Molecular Weight: 461.38
- MDL number: MFCD00866772
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:02
What is LOXIGLUMIDE?
The Uses of LOXIGLUMIDE
Loxiglumide is a CCK1 antagonist. Suppresses CCK-induced proliferation of acinar cells. Inhibits pancreatic secretion of digestive enzymes. Active in vivo.
Definition
ChEBI: Loxiglumide is an organic molecular entity.
Biochem/physiol Actions
Loxiglumide is a small-molecule antagonist of the cholecystokinin receptor CCKA. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying.
Safety Profile
A poison by intravenous. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx and Cl-.
Storage
Store at -20°C
Properties of LOXIGLUMIDE
| Melting point: | 113-115℃ |
| Boiling point: | 632.2±55.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| pka | pKa ~5(at 25℃) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 107097-80-3 |
Safety information for LOXIGLUMIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LOXIGLUMIDE
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