LMK-235

Synonym(s):N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide

CAS NO.：1418033-25-6
Empirical Formula: C15H22N2O4
Molecular Weight: 294.35
MDL number: MFCD26522892
EINECS: 808-770-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-18 22:22:14

What is LMK-235?

Description

Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression. LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC₅₀s = 12 and 4 nM, respectively) over other HDACs (IC₅₀s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively). It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA or trichostatin A . LMK 235 and derivatives inhibit the growth of the malarial parasite P. falciparum at multiple life cycle stages at nanomolar concentrations.

The Uses of LMK-235

LMK 235 is a histone deacetylase (HDAC)4 and HDAC5 inhibitor and has shown to have enhanced cytotoxic effects against the human cancer cell lines A2780, Cal27, Kyse510, and MDA-MB231.

What are the applications of Application

LMK 235 is a HDAC4 and HDAC5 inhibitor

Biochem/physiol Actions

LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.

Properties of LMK-235

Melting point:	135-138°C
Density	1.155±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	9.46±0.20(Predicted)
color	white to beige

Safety information for LMK-235

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.