LITHIUM TETRAMETHYLPIPERIDIDE
Synonym(s):2,2,6,6-Tetramethylpiperidine lithium salt (1:1);LTMP
- CAS NO.：38227-87-1
- Empirical Formula: C9H18LiN
- Molecular Weight: 147.19
- MDL number: MFCD00015910
- EINECS: 684-475-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:12:35
What is LITHIUM TETRAMETHYLPIPERIDIDE?
The Uses of LITHIUM TETRAMETHYLPIPERIDIDE
Lithium 2,2,6,6-tetramethylpiperidide is a strong base and can be used:
- For the synthesis of enamines from terminal epoxides through trans-α-lithiated epoxide as an intermediate.
- For ortholithiation of arenes such as 1,3-bis(trifluoromethyl)benzene, 4,4-dimethyl-2-phenyl-2-oxazoline, 1,4-bis(trifluoromethyl)benzene and 1,3-dimethoxybenzene.
- In combination with Lewis donor ligand, N,N,N′,N′-tetramethylethylenediamine (TMEDA) for deprotonative metalation of methoxy-substituted arenes.{21]
Safety information for LITHIUM TETRAMETHYLPIPERIDIDE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H261:Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P231+P232:Handle under inert gas. Protect from moisture. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P422:Store contents under … |
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