Leupeptin hydrochloride
Synonym(s):Acetyl-Leu-Leu-Arg-al hydrochloride
- CAS NO.：24125-16-4
- Empirical Formula: C20H38N6O4.ClH
- Molecular Weight: 463.02
- MDL number: MFCD00133457
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:53:06
What is Leupeptin hydrochloride?
Chemical properties
solid
The Uses of Leupeptin hydrochloride
Leupeptin Hydrochloride is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay.
What are the applications of Application
Leupeptin hydrochloride is a calpain, cysteine, and protease inhibitor
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Properties of Leupeptin hydrochloride
| storage temp. | -20°C |
| Stability: | Stable, but store cold. Incompatible with strong bases, strong acids. |
Safety information for Leupeptin hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Leupeptin hydrochloride
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