LAPAQUISTAT
Synonym(s):1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;Lapaquistat acetate;TAK 475
- CAS NO.：189060-13-7
- Empirical Formula: C33H41ClN2O9
- Molecular Weight: 645.14
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is LAPAQUISTAT?
The Uses of LAPAQUISTAT
A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.
What are the applications of Application
Lapaquistat Acetate is Lapaquistat Acetate is an inhibitor of Squalene synthetase.
Properties of LAPAQUISTAT
| Melting point: | 194-196℃ |
| Boiling point: | 826.4±65.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.66±0.10(Predicted) |
| color | White |
Safety information for LAPAQUISTAT
Computed Descriptors for LAPAQUISTAT
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