L-NORPSEUDOEPHEDRINE

CAS NO.：37577-07-4
Empirical Formula: C9H13NO
Molecular Weight: 151.21
MDL number: MFCD01711267
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:22:43

What is L-NORPSEUDOEPHEDRINE?

The Uses of L-NORPSEUDOEPHEDRINE

An enatiomer of (+)-Pseudonorephedrine (P839585). (-)-Pseudonorephedrine is metabolite of Cathinone (C225700) and possesses amphetamine-like stimulus properties. Studies show that (-)-Pseudonorephedri ne enhances the analgesic and rate decreasing effects of Morphine (M652290) but inhibits discriminative properties.

Definition

ChEBI: Phenylpropanolamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations. It has a role as a sympathomimetic agent and a nasal decongestant.

Purification Methods

Purify (-)-nor--ephedrine by recrystallisation from H2O, MeOH, EtOH, Et2O/pet ether or *C6H6 (plates). The mandelate salt has m 163.5o (from EtOH/Et2O) and [] D -41.3o (c 0.8, H2O) [Jarowski & Hartung J Org Chem 8 564 566 567 1943]. The hydrochloride is purified by dissolving 1.44g in 96% EtOH (5mL), adding Et2O (16mL) and cooling; it has m 178-179o (m180-181o is also reported) and [] 30D -42.9o (c 1.8, H2O) [Fles & Markovac-Prpic Croat Chem Acta 29 186 1957]. [Beilstein 13 I 252, 13 II 370, 13 III 1716, 13 IV 1874.]

Properties of L-NORPSEUDOEPHEDRINE

Melting point:	77-78 °C
Boiling point:	288.1±20.0 °C(Predicted)
Density	1.071±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	12.07±0.45(Predicted)
EPA Substance Registry System	Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)- (37577-07-4)

Safety information for L-NORPSEUDOEPHEDRINE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L-NORPSEUDOEPHEDRINE

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