CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | White, crystalline powder |
|---|---|
| Odor | Slight aromatic odor |
| Melting Point | 101-101.5 °C |
| Solubility | Freely soluble in water and alcohol |
| LogP | log Kow = 0.67 |
| Decomposition | When heated to decomposition it emits very toxic fumes of nitroxides. |
| Dissociation Constants | pKa = 9.44 (conjugate acid) |
| Other Experimental Properties | Crystals; melting point 190-194 °C; odor resembling that of crude benzoic acid; pKa 9.44 + or - 0.04. Freely soluble in water, alcohol; practically insoluble in ether, chloroform, benzene. The aq soln is neutral to litmus. /Phenylpropanolamine hydrochloride/ |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 151.21 g/mol |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 151.099714038 g/mol |
| Monoisotopic Mass | 151.099714038 g/mol |
| Topological Polar Surface Area | 46.2 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 110 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Phenylpropanolamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations. It has a role as a sympathomimetic agent and a nasal decongestant.