L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Synonym(s):L -γ-Glutamyl-p-nitroanilide
- CAS NO.：67953-08-6
- Empirical Formula: C11H14ClN3O5
- Molecular Weight: 303.7
- MDL number: MFCD00039054
- EINECS: 267-944-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE?
Description
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
The Uses of L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.
What are the applications of Application
L-Glutamic acid γ-(p-nitroanilide) hydrochloride is a substrate for gamma-glutamyl transpeptidase (GGT).
References
1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521
Properties of L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
| storage temp. | 2-8°C |
| solubility | Soluble in Water (up to 5 mg/ml). |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. |
| EPA Substance Registry System | L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6) |
Safety information for L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
You may like
-
L-Glutamic acid gamma-(p-nitroanilide) CAS 67953-08-6View Details
67953-08-6 -
L-Glutamic acid γ-(p-nitroanilide) hydrochloride CAS 67953-08-6View Details
67953-08-6 -
4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 98+View Details
101894-09-1 -
4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 83883-25-4 98+View Details
83883-25-4 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6