L-655,708
Synonym(s):Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;L-655708
- CAS NO.：130477-52-0
- Empirical Formula: C18H19N3O4
- Molecular Weight: 341.36
- MDL number: MFCD02684528
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:24
What is L-655,708?
The Uses of L-655,708
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.
What are the applications of Application
L-655,708 is a potent and selective inverse agonist for the benzodiazepine
Biological Activity
Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Biochem/physiol Actions
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
Storage
Desiccate at +4°C
Properties of L-655,708
| Melting point: | 175-176 °C |
| Boiling point: | 584.4±50.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 6 mg/mL |
| form | powder |
| pka | 1.49±0.20(Predicted) |
| color | White to yellow |
Safety information for L-655,708
Computed Descriptors for L-655,708
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![1-[2-(1H-IMIDAZOL-1-YL)PHENYL]METHANAMINE](https://img.chemicalbook.in/CAS/GIF/25373-55-1.gif)
![[3H]-L-655,708,L-655,708, [1',1',1'-3H]](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB5430909.gif)
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