L(+)-2-Aminobutyric acid
Synonym(s):L -α-Aminobutyric acid
- CAS NO.：1492-24-6
- Empirical Formula: C4H9NO2
- Molecular Weight: 103.12
- MDL number: MFCD00064415
- EINECS: 216-083-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is L(+)-2-Aminobutyric acid?
Chemical properties
White Crystalline Solid
The Uses of L(+)-2-Aminobutyric acid
Receptor antagonist
The Uses of L(+)-2-Aminobutyric acid
aminobutyric acid is an amino acid with water-binding properties and possible anti-inflammatory capacities.
The Uses of L(+)-2-Aminobutyric acid
L-(+)-2-Aminobutyric acid is used in the biosynthesis of nonribosomal peptides. It acts as a receptor antagonist. It is also used as a chiral reagent. Further, it is used in the determination of substrate of glutamyl cysteine acid synthase. In addition to this, it is also utilized as a drug intermediate.
What are the applications of Application
L-Aminobutyric Acid is a receptor antagonist
Definition
ChEBI: An optically active form of alpha-aminobutyric acid having L-configuration.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 450, 1946 DOI: 10.1021/ja01207a032
General Description
L-2-Aminobutyric acid is synthesized from L-threonine and L-aspartic acid through a ?-transamination reaction. It is an L-alanine analogue with an ethyl side chain.
Biochem/physiol Actions
L-α-Aminobutyric acid (AABA) is an isomer of the non-natural amino acid aminobutyric acid with activity in the γ-glutamyl cycle that regulates glutathione biosynthesis. Recently AABA has been studied as a supplement to in vitro maturation medium (NCSU 23 medium) for culture of oozytes and embryos. This product has been qualified for use in cell culture. AABA is also used as a substitute amino acid for alanine in studies on peptide function.
Purification Methods
Crystallise butyrine from aqueous EtOH, and the melting point depends on heating rate but has m 303o in a sealed tube. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2399 IR: 2401 1961, Beilstein 4 III 1294, 4 IV 2584.]
Properties of L(+)-2-Aminobutyric acid
| Melting point: | 300 °C |
| Boiling point: | 215.2±23.0 °C(Predicted) |
| alpha | 21.6 º (c=2, 5N HCl) |
| Density | 1.2300 (estimate) |
| refractive index | 1.4650 (estimate) |
| storage temp. | room temp |
| solubility | 22.7 g/100 mL (22°C) |
| form | Crystalline Powder |
| pka | 2.29(at 25℃) |
| color | White to beige |
| Water Solubility | 22.7 g/100 mL (22 ºC) |
| Merck | 14,428 |
| BRN | 1720935 |
| CAS DataBase Reference | 1492-24-6(CAS DataBase Reference) |
| NIST Chemistry Reference | (l)-2-Aminobutanoic acid(1492-24-6) |
| EPA Substance Registry System | Butanoic acid, 2-amino-, (2S)- (1492-24-6) |
Safety information for L(+)-2-Aminobutyric acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for L(+)-2-Aminobutyric acid
| InChIKey | QWCKQJZIFLGMSD-VKHMYHEASA-N |
L(+)-2-Aminobutyric acid manufacturer
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