Kinsenoside

CAS NO.：151870-74-5
Empirical Formula: C10H16O8
Molecular Weight: 264.23
MDL number: MFCD11100290
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is Kinsenoside?

Description

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

The Uses of Kinsenoside

Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.

Definition

ChEBI: (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.

Properties of Kinsenoside

Boiling point:	570.2±50.0 °C(Predicted)
Density	1.59±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM) DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM)
form	A crystalline solid
pka	12.81±0.70(Predicted)
color	White to light yellow