Corosolic acid
Synonym(s):Corosolic acid;2α-Hydroxyursolic acid;Glucosol;Colosolic acid;(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid
- CAS NO.:4547-24-4
- Empirical Formula: C30H48O4
- Molecular Weight: 472.7
- MDL number: MFCD06794973
- EINECS: 610-253-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is Corosolic acid?
Description
Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.
The Uses of Corosolic acid
(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum or activity
Properties of Corosolic acid
Melting point: | 243~245℃ |
Boiling point: | 573.3±50.0 °C(Predicted) |
Density | 1.14±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | methanol: soluble1mg/mL, clear, colorless |
form | neat |
color | White |
Safety information for Corosolic acid
Computed Descriptors for Corosolic acid
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