JNJ-42847922
- CAS NO.：1293281-49-8
- Empirical Formula: C21H22FN7O
- Molecular Weight: 407.44
- MDL number: MFCD31700700
- Update Date: 2026-01-21 16:49:52
What is JNJ-42847922?
Description
Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.
Properties of JNJ-42847922
| Boiling point: | 667.7±65.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 250 mg/mL (613.59 mM) |
| pka | 6.50±0.50(Predicted) |
| form | Solid |
| color | White to yellow |
Safety information for JNJ-42847922
Computed Descriptors for JNJ-42847922
JNJ-42847922 manufacturer
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