ITE
- CAS NO.：448906-42-1
- Empirical Formula: C14H10N2O3S
- Molecular Weight: 286.31
- MDL number: MFCD06411597
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-16 19:33:17
What is ITE?
The Uses of ITE
ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.
Definition
ChEBI: 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester is an indolyl carboxylic acid.
Biological Activity
Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β -naphthoflavone. Active in vivo .
Storage
Store at RT
Properties of ITE
| Melting point: | 234 - 236°C |
| Boiling point: | 520.4±48.0 °C(Predicted) |
| Density | 1.427±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 30 mg/mL, soluble |
| form | solid |
| pka | 14.38±0.30(Predicted) |
| color | Off-White to Light Yellow |
Safety information for ITE
Computed Descriptors for ITE
New Products
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