ISOGUVACINE HYDROCHLORIDE

Synonym(s):1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

CAS NO.：64603-90-3
Empirical Formula: C6H9NO2
Molecular Weight: 127.14
MDL number: MFCD00055192
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:41

What is ISOGUVACINE HYDROCHLORIDE?

Description

This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.

Chemical properties

bp 195-197°C

The Uses of ISOGUVACINE HYDROCHLORIDE

A GABAA receptor agonist. Anticonvulsant; antiepileptic.

Definition

ChEBI: Isoguvacine is a tetrahydropyridine.

Biological Activity

Specific GABA A receptor agonist.

References

Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)

Properties of ISOGUVACINE HYDROCHLORIDE

Melting point:	220 °C
Boiling point:	280.8±35.0 °C(Predicted)
Density	1.199±0.06 g/cm3(Predicted)
RTECS	US5908286
storage temp.	Store at RT
solubility	H₂O: refrigerate if not used immediately.soluble
form	solid
pka	pK1:9.07 (25°C)
color	white
Water Solubility	Soluble in water

Safety information for ISOGUVACINE HYDROCHLORIDE

Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.