(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
Synonym(s):Pinc
- CAS NO.：73789-56-7
- Empirical Formula: C19H15N2P
- Molecular Weight: 302.309561
- MDL number: MFCD09038528
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE?
The Uses of (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
Despite growing interest for therapeutic and other biological applications, cyclic peptidomimetics are challenging to synthesize. As reported by the lab of Andrei Yudin, (N-isocyanoimino)triphenylphosphorane (Pinc
) enables zwitterionic-controlled generation of peptide macrocyles from linear peptides and aldehydes. Containing a 1,3,4-oxadiazole, the resulting peptide exhibits both improved membrane permeability, lipophilicity, and aqueous solubility.
Different functional groups can be introduced by varying the aldehyde, and initial work used propionaldehyde (538124), phenylacetaldehyde (107395), and isovaleraldehyde (146455).
Properties of (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
| Melting point: | 160-161 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| color | White to Light yellow to Light orange |
Safety information for (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
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