IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
- CAS NO.：39028-27-8
- Empirical Formula: C6H6INO4
- Molecular Weight: 283.02
- MDL number: MFCD00058451
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:03
What is IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER?
Description
SIA Crosslinker is a non-cleavable, water-soluble crosslinker containig an NHS ester and an iodine group. The NHS ester is reactive toward amines while the iodine reacts with thiol groups.
Chemical properties
White Solid
The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms
The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
forms water soluble carboxylate derivatives
The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms
What are the applications of Application
N-Succinimidyl Iodoacetate is an amine and sulfhydryl reactive crosslinker, 1.5 angstrom spacer arm
Biological Activity
SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
| Melting point: | 148°C |
| Boiling point: | 315.6±44.0 °C(Predicted) |
| Density | 2.11±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 50 mg/mL |
| form | powder |
| color | White to Off-White |
Safety information for IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
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