L-Prolinamide, 3-methyl-N′-[28,28,28-trichloro-1,19,25-trioxo-27-(2-pyrimidinylamino)-4,7,10,13,16,24-hexaoxa-20,26-diazaoctacos-1-yl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

CAS NO.：2509359-75-3
Empirical Formula: C46H66Cl3N9O12S
Molecular Weight: 1075.5
Update Date: 2026-04-21 11:20:27

What is L-Prolinamide, 3-methyl-N′-[28,28,28-trichloro-1,19,25-trioxo-27-(2-pyrimidinylamino)-4,7,10,13,16,24-hexaoxa-20,26-diazaoctacos-1-yl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-?

Biological Activity

CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation[1]. CP5V comprises a Cdc20 ligand and VHL binding moiety bridged by a PEG5 linker that induces Cdc20 degradation. CP5V induces degradation of Cdc20 leading to significant inhibition of breast cancer cell proliferation and resensitization of Taxol-resistant cell lines[1].CP5V profoundly degrades Cdc20 in both MCF7 and MDA-MB-231 cells with DC50 being approximately 1.6 μM[1].

References

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

Properties of L-Prolinamide, 3-methyl-N′-[28,28,28-trichloro-1,19,25-trioxo-27-(2-pyrimidinylamino)-4,7,10,13,16,24-hexaoxa-20,26-diazaoctacos-1-yl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

Density	1.326±0.06 g/cm3(Predicted)
solubility	DMSO : 150 mg/mL (139.47 mM; Need ultrasonic)
pka	9.83±0.46(Predicted)
form	Solid
color	Off-white to light yellow

Safety information for L-Prolinamide, 3-methyl-N′-[28,28,28-trichloro-1,19,25-trioxo-27-(2-pyrimidinylamino)-4,7,10,13,16,24-hexaoxa-20,26-diazaoctacos-1-yl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

Computed Descriptors for L-Prolinamide, 3-methyl-N′-[28,28,28-trichloro-1,19,25-trioxo-27-(2-pyrimidinylamino)-4,7,10,13,16,24-hexaoxa-20,26-diazaoctacos-1-yl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

New Products

2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one