Ilorasertib hydrochloride

CAS NO.：1847485-91-9
Empirical Formula: C25H22ClFN6O2S
Molecular Weight: 525
MDL number: MFCD32201158
Update Date: 2025-10-29 15:43:00

What is Ilorasertib hydrochloride?

Description

Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].

References

[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

Properties of Ilorasertib hydrochloride

storage temp.	Store at -20°C
solubility	DMSO: 41.67 mg/mL (79.37 mM)
form	Solid
color	White to off-white

Safety information for Ilorasertib hydrochloride

Computed Descriptors for Ilorasertib hydrochloride

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