IEM 1460

Description

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC₅₀ = 10 μM-0.1 mM). It is selective for Ca²⁺-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca²⁺-permeable glutamate receptors in the brain.

The Uses of IEM 1460

IEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents.

What are the applications of Application

IEM 1460 is an Adamantane derivative and open-chennel blocker of AMPA currents

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

Storage

Room temperature (desiccate)