HSP70 modulator 115-7c

Description

Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1?The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.2?Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.3,4?Compound 115-7c is an important probe for understanding HSP70 functions.4

Definition

ChEBI: 4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid is a carboxylic ester. It is functionally related to a benzyl alcohol.

References

1) Wisen?et al. (2010),?Binding of a small molecule at the protein-protein interface regulates the chaperone activity of hsp70-hsp40;? ACS Chem. Biol.,?5?611 2) Jinwal?et al. (2010),?Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;? Mol. Cell Pharmacol.,?2?43 3) Chafekar?et al. (2012),?Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;? ACS Chem. Biol.,?7?1556 4) Walter?et al. (2011),?Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;? J. Biol. Chem.,?286?40486