17-GMP-APA-GA
- Molecular Weight: 0
- Update Date: 2025-08-06 15:14:14
What is 17-GMP-APA-GA?
Description
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
The Uses of 17-GMP-APA-GA
17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates.
References
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460 2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786 3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
Properties of 17-GMP-APA-GA
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | solid |
| color | Purple |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day. |
Safety information for 17-GMP-APA-GA
Computed Descriptors for 17-GMP-APA-GA
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