Herboxidiene

Description

Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2?Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3?Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4?Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5

The Uses of Herboxidiene

Herboxidiene is an anticancer agent. Herboxidiene is used in the lowering of plasma cholesterol, pre-mRNA splicing-modulatory action and in anti-tumor activity in numerous cell lines. It also exhibits herbicidal properties.

References

1) Miller-Wideman?et al.?(1992),?Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physio-chemical and biological properties; J. Antibiot. (Tokyo),?45?914 2) Gao?et al.?(2013),?Comparison of splicing factor 3b inhibitors in human cells; Chembiochem,?14?49 3) Hasegawa?et al.?(2011),?Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product; ACS Chem. Biol.,?6?229 4) Jung?et al.?(2015),?Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α; Arch. Pharm. Res.,?38?1728 5) Martinez-Montiel?et al.?(2016),?Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment;?Biomed. Res. Int.,?2016?3681094