GW 610

Synonym(s):5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610;NSC 721648 - CAS 872726-44-8 - Calbiochem

CAS NO.：872726-44-8
Empirical Formula: C15H12FNO2S
Molecular Weight: 289.3246832
MDL number: MFCD12024619
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is GW 610?

Description

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI₅₀) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.

The Uses of GW 610

GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity.

What are the applications of Application

NSC 721648 is an antiproliferative benzothiazole compound

Properties of GW 610

Melting point:	110 °C
Boiling point:	422.8±55.0 °C(Predicted)
Density	1.293±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM) DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM)
form	White crystalline solid
pka	0.73±0.10(Predicted)
color	Light yellow to brown

Safety information for GW 610

Computed Descriptors for GW 610

New Products

2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one