GW 610

Synonym(s):5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610;NSC 721648 - CAS 872726-44-8 - Calbiochem

CAS NO.：872726-44-8
Empirical Formula: C15H12FNO2S
Molecular Weight: 289.3246832
MDL number: MFCD12024619
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is GW 610?

Description

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI₅₀) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.

The Uses of GW 610

GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity.

What are the applications of Application

NSC 721648 is an antiproliferative benzothiazole compound

Properties of GW 610

Melting point:	110 °C
Boiling point:	422.8±55.0 °C(Predicted)
Density	1.293±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM) DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM)
form	White crystalline solid
pka	0.73±0.10(Predicted)
color	Light yellow to brown

Safety information for GW 610

Computed Descriptors for GW 610

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