GUANYLIN (RAT)

Description

Guanylin is a peptide hormone consisting of 15 aa residues that binds to the guanylyl cyclase C (GUCY2C) receptor to produce cGMP. It plays an important role in regulating ion and water transport and maintaining epithelial homeostasis in the intestine and kidney. Eel renoguanylin (Rgn) is more similar to GN than to uroguanylin (UGN), and thus is described here.

The Uses of GUANYLIN (RAT)

Guanylin (rat, mouse) is an endogenous intestinal guanylyl cyclase activator.

What are the applications of Application

Guanylin (rat, mouse) is a gastrointestinal peptide hormone and intestinal guanyl cyclase C activator.

Clinical Use

Two GN/UGN agonists, linaclotide and plecanatide, have recently been approved in the United States, European Union, Japan, and other countries to treat irritable bowel syndrome and chronic constipation. They have also been approved in the United States to treat chronic idiopathic constipation and irritable bowel syndrome with constipation, respectively.