GSK2795039

Synonym(s):GSK 2795039;GSK-2795039;N-(1-Isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

CAS NO.：1415925-18-6
Empirical Formula: C23H26N6O2S
Molecular Weight: 450.56
MDL number: MFCD30489720
Update Date: 2026-04-22 18:57:36

What is GSK2795039?

Biological Activity

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.

in vitro

GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.

Apoptosis Analysis p>

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Cell Line:	PC12 cells
25 μM
Incubation Time:
Result:	Reduced apoptosis among PC12 cells.

Storage

Store at -20°C

Properties of GSK2795039

Boiling point:	691.5±65.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM) DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM) DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)
form	A solid
pka	6.99±0.30(Predicted)
color	White to yellow