GSK-3β Inhibitor XVIII
Synonym(s):2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
- CAS NO.：1139875-74-3
- Empirical Formula: C20H20ClN5OS
- Molecular Weight: 413.92
- MDL number: MFCD32671859
- Update Date: 2026-07-14 16:49:18
What is GSK-3β Inhibitor XVIII?
Description
GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.
Properties of GSK-3β Inhibitor XVIII
| Boiling point: | 632.3±65.0 °C(Predicted) |
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMSO: soluble |
| pka | 6?+-.0.10(Predicted) |
| form | White solid |
| color | White to off-white |
Safety information for GSK-3β Inhibitor XVIII
Computed Descriptors for GSK-3β Inhibitor XVIII
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