GSK-3β Inhibitor XVIII
Synonym(s):2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
- CAS NO.：1139875-74-3
- Empirical Formula: C20H20ClN5OS
- Molecular Weight: 413.92
- MDL number: MFCD32671859
- Update Date: 2026-07-27 17:00:41
What is GSK-3β Inhibitor XVIII?
Description
GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.
Properties of GSK-3β Inhibitor XVIII
| Boiling point: | 632.3±65.0 °C(Predicted) |
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMSO: soluble |
| pka | 6?+-.0.10(Predicted) |
| form | White solid |
| color | White to off-white |
Safety information for GSK-3β Inhibitor XVIII
Computed Descriptors for GSK-3β Inhibitor XVIII
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone](https://img.chemicalbook.in/CAS2/GIF/371242-69-2.gif)
![N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE](https://img.chemicalbook.in/CAS/GIF/853625-60-2.gif)
You may like
-
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1 -
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1 -
13227-01-5 98+View Details
13227-01-5 -
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1 -
13227-01-5 98+View Details
13227-01-5 -
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1 -
13227-01-5 98+View Details
13227-01-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.