Motesanib
- CAS NO.：453562-69-1
- Empirical Formula: C22H23N5O
- Molecular Weight: 373.45
- MDL number: MFCD10567689
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-22 20:19:50
What is Motesanib?
Chemical properties
Pale Yellow Solid
The Uses of Motesanib
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
The Uses of Motesanib
Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
What are the applications of Application
Motesanib is an inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.
Definition
ChEBI: Motesanib is a pyridinecarboxamide.
Properties of Motesanib
| Melting point: | 147-150°C |
| Boiling point: | 517.3±50.0 °C(Predicted) |
| Density | 1.251 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White powder solid. |
| pka | 11.75±0.40(Predicted) |
| color | Pale Yellow |
Safety information for Motesanib
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Motesanib
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