Fosmidomycin
Synonym(s):(3-(Formylhydroxyamino)propyl)phosphonic acid sodium salt;(3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt;FR 31564
- CAS NO.：66508-53-0
- Empirical Formula: C4H10NO5P
- Molecular Weight: 183.1
- MDL number: MFCD00865023
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:15
What is Fosmidomycin?
The Uses of Fosmidomycin
Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.
Definition
ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i the non-mevalonate pathway of isoprenoid biosynthesis.
Biochem/physiol Actions
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).
Properties of Fosmidomycin
| Melting point: | 158-160° (dec); mp 160-166° (dec) (Hemmi) |
| storage temp. | -20°C |
| solubility | H2O: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
Safety information for Fosmidomycin
Computed Descriptors for Fosmidomycin
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