Forodesine
- CAS NO.：209799-67-7
- Empirical Formula: C11H14N4O4
- Molecular Weight: 266.25
- MDL number: MFCD09837827
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Forodesine?
Description
Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).
The Uses of Forodesine
Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.
The Uses of Forodesine
Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.
Definition
ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.
Properties of Forodesine
| Boiling point: | 613.5±65.0 °C(Predicted) |
| Density | 2.01 |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | PBS (pH 7.2): 5 mg/ml |
| form | A crystalline solid |
| pka | 13.88±0.70(Predicted) |
| color | Light brown to gray |
Safety information for Forodesine
Computed Descriptors for Forodesine
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE](https://img.chemicalbook.in/CAS/GIF/5655-01-6.gif)
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