Fmoc-Val-Ala-PAB-OH
- CAS NO.：1394238-91-5
- Empirical Formula: C30H33N3O5
- Molecular Weight: 515.6
- MDL number: MFCD28557282
- Update Date: 2025-07-16 09:56:27
What is Fmoc-Val-Ala-PAB-OH?
Description
Fmoc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
The Uses of Fmoc-Val-Ala-PAB-OH
Fmoc-Val-Ala-PAB is a building block used in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.
Properties of Fmoc-Val-Ala-PAB-OH
| Melting point: | 218 °C(dec.) |
| Boiling point: | 811.1±65.0 °C(Predicted) |
| Density | 1.251±0.06 g/cm3(Predicted) |
| solubility | DMSO : 33.33 mg/mL (64.64 mM; ultrasonic and warming and heat to 80°C) |
| pka | 10.63±0.46(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
Safety information for Fmoc-Val-Ala-PAB-OH
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fmoc-Val-Ala-PAB-OH
New Products
6-Methyl-2-(p-tolyl)imidazo[1,2-a]pyridine 4-FLUOROBENZOYLACETONITRILE (S)-Glycidyl Phthalimide Maleic hydrazide 8-Bromo-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 4-Nitroacetophenone DL-Glutamic acid 3-Nitroacetophenone 3,4-Dihydroxyacetophenone 3,4-Dimethoxyacetophenone 4'-Hydroxyacetophenone 3-Hydroxy-2-methylbenzoic acid 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 3-acetyl pyridine 4-FORMYL-N-CBZ-PIPERIDINE 2-pyridineacetonitrile 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Trenbolone acetate 4-Bromobenzaldehyde 4-bromo-2-ethyl-3-fluorobenzoic acid 6-(chloromethyl)pteridine-2,4-diamine monohydrochloride 2-Chlorophenyl diphenyl chloromethaneRelated products of tetrahydrofuran
You may like
-
Fmoc-Val-Ala-PAB-OH CAS 1394238-91-5View Details
1394238-91-5 -
586-37-8 98+View Details
586-37-8 -
1-Boc-Azetidine-3-yl-methanol 98+View Details
142253-56-3 -
1197-09-7' 98+View Details
1197-09-7' -
3,4-Dimethoxyacetophenone 98+View Details
1131-62-0 -
4-Acetylbiphenyl 92-91-1 98+View Details
92-91-1 -
99-93-4 98+View Details
99-93-4 -
Triisopropyl Borate (TIPB)View Details
5419-55-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.