FK 888

Synonym(s):(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate;FK888 hydrate;N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate

CAS NO.：138449-07-7
Empirical Formula: C36H36N4O4
Molecular Weight: 588.7
MDL number: MFCD00274042
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is FK 888?

The Uses of FK 888

FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.

Definition

ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.

Biological Activity

Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

Storage

Store at -20°C

Properties of FK 888

Boiling point:	901.9±65.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥13mg/mL
form	powder
pka	13.01±0.40(Predicted)
color	white to tan
optical activity	[α]/D -135 to -145°, c = 1 in methanol