Fenpyroximate

The Uses of Fenpyroximate

Acaricide.

Definition

ChEBI: Fenpyroximate is a pyrazole acaricide and a tert-butyl ester. It has a role as a mitochondrial NADH:ubiquinone reductase inhibitor. It derives from a hydride of a 1H-pyrazole.

Agricultural Uses

Acaricide, Miticide, Insecticide: Used to control spider mites in greenhouses.

Trade name

AKARI®; HOE® 555-02A; NNI®-850; SEQUEL®

Metabolic pathway

When fenpyroximate is administered orally to rats, radiocarbons from 14C-fenpyroximate are rapidly and almost completely excreted in the urine and feces within 72 h, and fenyproximate seems to be metabolized via oxidation of the tert-butyl group and methyl group at the 3-position in the pyrazole ring, p- hydroxylation in the phenoxy moiety, N-demethylation, hydrolysis of the tert-butyl ester, cleavage of the oxime ether bond, and/or E/Z isomerization. In soils, 12 degradation products are identified, and in sterilized soils the degradation of fenpyroximate and CO2, evolution are negligible. Fenpyroximate degrades through hydrolysis of tert-butyl ester, isomerization or cleavage of the oxime ether, N-demethylation, oxidation of the methyl group at the 3-position on the pyrazole ring, and hydroxylation of the phenoxy ring, and is finally mineralized to CO2 and/or bound to soil organic matter.