Zoledronic acid
Synonym(s):[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate;Zoledronate monohydrate;Zoledronic acid monohydrate
- CAS NO.:118072-93-8
- Empirical Formula: C5H10N2O7P2
- Molecular Weight: 272.09
- MDL number: MFCD00867791
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-15 17:37:19
![Zoledronic acid Structural](https://img.chemicalbook.in/CAS/GIF/118072-93-8.gif)
What is Zoledronic acid?
Absorption
A 4mg intravenous dose reaches a Cmax of 370±78.5ng/mL, with a Tmax of 0.317±0.014h, and an AUC of 788±181ng*h/mL. A 5mg intravenous dose reaches a Cmax of 471±76.1ng/mL, with a Tmax of 0.368±0.005h, and an AUC of 917±226ng*h/mL.
Toxicity
Patients experiencing an overdose may present with renal impairment, hypocalcemia, hypophosphatemia, and hypomagnesemia. Overdose should be managed through intravenous administration of the insufficient ions.
Description
Zoledronic acid is a white, crystalline powder that is available in vials for reconstitution for IV infusion over at least 15 minutes. It does not undergo metabolic transformation and does not inhibit CYP450 enzymes. Clearance of this agent is dependent on the patient's creatinine clearance, not on dose. Serum creatinine levels should be evaluated before every treatment. Zolendronic acid is contraindicated in patients with severe renal impairment.
The Uses of Zoledronic acid
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
What are the applications of Application
Zoledronic acid, anhydrous is a protein kinase C activator with apoptotic effects
Background
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. Zoledronic acid was first described in the literature in 1994.
Zoledronic acid was granted FDA approval on 20 August 2001.
Indications
Zoledronic acid is indicated to treat hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, osteoporosis in men and postmenopausal women, glucocorticoid induced osteoporosis, and Paget's disease of bone in men and women. Zoledronic acid is also indicated for the prevention of osteoporosis in post menopausal women and glucocorticoid induced osteoporosis.
Pharmacokinetics
Zoledronic acid is a third generation, nitrogen containing bisphosphonate that inhibits osteoclast function and prevents bone resorption. The therapeutic window is wide as patients are unlikely to suffer severe effects from overdoses and the duration of action is long. Patients should be counselled regarding the risk of electrolyte deficiencies, renal impairment, osteonecrosis of the jaw, atypical femoral fractures, bronchoconstriction, hepatic impairment, hypocalcemia, and embryo-fetal toxicity.
Metabolism
Zoledronic acid is not metabolized in vivio.
Properties of Zoledronic acid
Melting point: | 193-2040C (dec) |
Boiling point: | 764.0±70.0 °C(Predicted) |
Density | 2.13±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in Water (up to 2 mg/ml). |
form | solid |
color | White or off-white |
Safety information for Zoledronic acid
Computed Descriptors for Zoledronic acid
Abamectin manufacturer
Dr. Reddy's Laboratories Ltd
Shilpa Medicare Limited (SML)
Basil Drugs AND Pharmaceuticals Pvt Ltd
NATCO Pharma Limited
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 3-NITRO-5-ACETYL IMINODIBENZYL 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
![](https://img.chemicalbook.in/CAS/GIF/165800-07-7.gif)
![](https://img.chemicalbook.in/CAS/GIF/165800-06-6.gif)
![](https://img.chemicalbook.in/CAS/GIF/119302-91-9.gif)
![](https://img.chemicalbook.in/CAS/20180808/GIF/1134798-26-7.gif)
![](https://img.chemicalbook.in/CAS/GIF/75176-37-3.gif)
![](https://img.chemicalbook.in/CAS/GIF/35575-96-3.gif)
You may like
-
118072-93-8 Zoledronic Acid 98%View Details
118072-93-8 -
Zoledronic Acid 98%View Details
-
Zoledronic Acid 118072-93-8 98%View Details
118072-93-8 -
118072-93-8 98%View Details
118072-93-8 -
Zoledronic Acid 98%View Details
118072-93-8 -
118072-93-8 Zoledronic Acid 98%View Details
118072-93-8 -
Zoledronic Acid 98%View Details
118072-93-8 -
Zoledronic Acid 118072-93-8 99%View Details
118072-93-8