FC 131

CAS NO.：606968-52-9
Empirical Formula: C36H47N11O6
Molecular Weight: 729.83
MDL number: MFCD28160535
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is FC 131?

Description

C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC₅₀ = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC₅₀ = 73 nM). FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.

The Uses of FC 131

Cyclo[3-?(2-?naphthalenyl)?-?L-?alanylglycyl-?D-?tyrosyl-?L-?arginyl-?L-?arginyl] is a CXCR4 antagonist with anti-HIV properties.

What are the applications of Application

FC 131 is an antagonist of CXCR4 with anti-HIV activity

Definition

ChEBI: Cyclo[3-(2-naphthalenyl)-l-alanylglycyl-d-tyrosyl-l-arginyl-l-arginyl] is an oligopeptide.

Properties of FC 131

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
pka	9.89±0.15(Predicted)
form	Powder
Water Solubility	Soluble to 2 mg/ml in water

Safety information for FC 131

Computed Descriptors for FC 131

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