F-AMidine

CAS NO.：877617-45-3
Empirical Formula: C14H19FN4O2
Molecular Weight: 294.32
MDL number: MFCD28138492
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 17:10:26

What is F-AMidine?

The Uses of F-AMidine

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Definition

ChEBI: F-Amidine is a N-acylglycine.

Properties of F-AMidine

Density	1.27±0.1 g/cm3(Predicted)
pka	13.26±0.46(Predicted)

Safety information for F-AMidine

Computed Descriptors for F-AMidine

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