Exendin-3 (9-39) amide
- CAS NO.：133514-43-9
- Empirical Formula: C149H234N40O47S
- Molecular Weight: 3369.76
- MDL number: MFCD02179664
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:12:29
What is Exendin-3 (9-39) amide?
Description
Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.
The Uses of Exendin-3 (9-39) amide
Biological probe.
The Uses of Exendin-3 (9-39) amide
Exendin-3 (9-39) is a potent and selective GLP-1 receptor antagonist.
What are the applications of Application
Exendin-3 (9-39) is a potent and selecive GLP-1 receptor antagonist.
General Description
Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin.
Biochem/physiol Actions
GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4.
Storage
Store at -20°C
Properties of Exendin-3 (9-39) amide
| Density | 1.51 |
| RTECS | LF2460000 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O : 50 mg/mL (14.84 mM; Need ultrasonic) |
| form | Solid |
| color | Off-white to pale purple |
| Water Solubility | Soluble in water at 1mg/ml |
Safety information for Exendin-3 (9-39) amide
Computed Descriptors for Exendin-3 (9-39) amide
| InChIKey | WSEVKKHALHSUMB-UHFFFAOYSA-N |
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