etomidoline
- CAS NO.：21590-92-1
- Empirical Formula: C23H29N3O2
- Molecular Weight: 379.5
- MDL number: MFCD00867691
- EINECS: 2444639
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-16 17:44:27
What is etomidoline?
Originator
Smedolin,Yamanouchi,Japan,1976
Definition
ChEBI: Etomidoline is an organic molecular entity.
Manufacturing Process
31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol)
are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution
5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added
and the resulted mixture is heated at 70°C for 1 hour, and then poured into
an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-
isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to
104°C) is obtained as a byproduct with the above compound. This latter
compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.
Therapeutic Function
Muscle relaxant
Properties of etomidoline
| Melting point: | 106-107° |
| Boiling point: | 507.34°C (rough estimate) |
| Density | 1.1315 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| pka | 8.75±0.10(Predicted) |
Safety information for etomidoline
Computed Descriptors for etomidoline
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![4-[2-(DIMETHYLAMINO)ETHOXY]ANILINE 97](https://img.chemicalbook.in/CAS/GIF/62345-76-0.gif)
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