Ethyl diethoxyphosphinylformate

Synonym(s):Ethyl diethoxyphospinylformate;O,O-diethyl ethoxycarbonylphosphonate;Triethyl phosphonoformate

CAS NO.：1474-78-8
Empirical Formula: C7H15O5P
Molecular Weight: 210.16
MDL number: MFCD00009108
EINECS: 216-016-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

Ethyl diethoxyphosphinylformate Structural

What is Ethyl diethoxyphosphinylformate?

Chemical properties

Clear colorless to slightly yellow liquid

The Uses of Ethyl diethoxyphosphinylformate

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

General Description

for synthesis

Purification Methods

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]

Properties of Ethyl diethoxyphosphinylformate

Boiling point:	135 °C12 mm Hg(lit.)
Density	1.11 g/mL at 25 °C(lit.)
refractive index	n20/D 1.423(lit.)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Methanol (Slightly)
form	neat
color	Colorless to Almost colorless
Specific Gravity	1.11
BRN	1781949
Stability:	Moisture Sensitive
CAS DataBase Reference	1474-78-8(CAS DataBase Reference)
NIST Chemistry Reference	Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry System	Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)

Safety information for Ethyl diethoxyphosphinylformate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.