Ethyl diethoxyphosphinylformate
Synonym(s):Ethyl diethoxyphospinylformate;O,O-diethyl ethoxycarbonylphosphonate;Triethyl phosphonoformate
- CAS NO.：1474-78-8
- Empirical Formula: C7H15O5P
- Molecular Weight: 210.16
- MDL number: MFCD00009108
- EINECS: 216-016-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:30
What is Ethyl diethoxyphosphinylformate?
Chemical properties
Clear colorless to slightly yellow liquid
The Uses of Ethyl diethoxyphosphinylformate
Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
General Description
for synthesis
Purification Methods
Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Properties of Ethyl diethoxyphosphinylformate
| Boiling point: | 135 °C12 mm Hg(lit.) |
| Density | 1.11 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | neat |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.11 |
| BRN | 1781949 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 1474-78-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8) |
| EPA Substance Registry System | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8) |
Safety information for Ethyl diethoxyphosphinylformate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for Ethyl diethoxyphosphinylformate
New Products
2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide o-Anisaldehyde 4-Bromobenzaldehyde 3-Fluorobenzaldehyde 2-Chlorobenzaldehyde 3-Amino-3-(3-fluorophenyl)propanoic acid 1-Propyl-4-piperidone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 1-Boc-4-cyanopiperidine ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Vardenafil Bis-sulphonamide(Dimer) Nitroso Irbesartan N-Nitroso Nortriptyline Sulfonic acid Impurity 2-(p-Tolyl)acetaldehyde 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
You may like
-
Ethyl Diethoxyphosphinylformate CAS 1474-78-8View Details
1474-78-8 -
Foscarnet Related Compound D CAS 1474-78-8View Details
1474-78-8 -
Deuterated Styrene-d8 19361-62-7 97-99%View Details
19361-62-7 -
1187989-89-4 97-99%View Details
1187989-89-4 -
(S)-2-Bromobutanoic acid 97-99%View Details
32659-49-7 -
665020-24-6 ethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate 97-99%View Details
665020-24-6 -
3-bromo-[1,1'-biphenyl]-2-amine 1620885-59-7 97-99%View Details
1620885-59-7 -
1503408-77-2 6-Chloro-3,4-dimethylpyridin-2-amine 97-99%View Details
1503408-77-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.