Ethyl diethoxyphosphinylformate
Synonym(s):Ethyl diethoxyphospinylformate;O,O-diethyl ethoxycarbonylphosphonate;Triethyl phosphonoformate
- CAS NO.：1474-78-8
- Empirical Formula: C7H15O5P
- Molecular Weight: 210.16
- MDL number: MFCD00009108
- EINECS: 216-016-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:30
What is Ethyl diethoxyphosphinylformate?
Chemical properties
Clear colorless to slightly yellow liquid
The Uses of Ethyl diethoxyphosphinylformate
Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
General Description
for synthesis
Purification Methods
Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Properties of Ethyl diethoxyphosphinylformate
| Boiling point: | 135 °C12 mm Hg(lit.) |
| Density | 1.11 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | neat |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.11 |
| BRN | 1781949 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 1474-78-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8) |
| EPA Substance Registry System | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8) |
Safety information for Ethyl diethoxyphosphinylformate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for Ethyl diethoxyphosphinylformate
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