Diethyl methylphosphonate
Synonym(s):Bis(diethoxyphosphinyl)methane;DEMP;Diethoxymethylphosphine oxide
- CAS NO.：683-08-9
- Empirical Formula: C5H13O3P
- Molecular Weight: 152.13
- MDL number: MFCD00009813
- EINECS: 211-667-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:22:08
What is Diethyl methylphosphonate?
Chemical properties
clear colorless liquid
The Uses of Diethyl methylphosphonate
Diethyl methylphosphonate is used as a precursor for the synthesis of gem-difluroalkenyphosphonate via reaction with alpha-trifluromethylstyrene. It is also used in the synthesis of phosphonylated peptides, fluoroalkyl alpha- and beta-aminophosphonates, pyridone alkaloids with neuritogenic activity and lipophilic meropenem-derived prodrugs. It is readily mineralized by photoexcited titanium dioxide (TiO2).
Properties of Diethyl methylphosphonate
| Boiling point: | 194 °C(lit.) |
| Density | 1.041 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 168 °F |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless to pale yellow |
| Water Solubility | Miscible with water. |
| BRN | 1753416 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 683-08-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Diethyl methanephosphonate(683-08-9) |
Safety information for Diethyl methylphosphonate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Diethyl methylphosphonate
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