Ethyl 4-bromoacetoacetate

CAS NO.：13176-46-0
Empirical Formula: C6H9BrO3
Molecular Weight: 209.04
MDL number: MFCD07783015
EINECS: 806-757-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-23 17:25:30

What is Ethyl 4-bromoacetoacetate?

Synthesis

To a solution of Ethyl acetoacetate (10.0 g, 76.9 mmol, 1 .0 eq) in acetic acid (30 mL) was added bromine (12.3 g, 76.9 mmol, 1 .0 eq) at 0 °C over 10 min. The mixture was stirred at 0 °C for 1 h, the solvent was removed under reduced pressure, and the residue was diluted with water (50 mL). The aqueous mixture was extracted with CH2CI2 (50 mL x 3). The combined organic layers were washed with brine (60 mL x 2), dried over MgS04 and concentrated under reduced pressure to give ethyl 4-bromo-3-oxobutanoate (14.3 g, 85 per cent) as a yellow oil.

Properties of Ethyl 4-bromoacetoacetate

Boiling point:	231.6 °C
Density	1.511
refractive index	1.5281 (estimate)
storage temp.	2-8°C(protect from light)
pka	9.56±0.46(Predicted)
form	liquid
color	Colourless

Safety information for Ethyl 4-bromoacetoacetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.