DROMETRIZOLE TRISILOXANE

Absorption

Drometrizole trisiloxane is reported as having little to no absorption through the skin . At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited . Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use .

Toxicity

Drometrizole trisiloxane is reported as having little to no absorption through the skin, which leads most national health agencies that approve its use in sunscreens (including the EU, Canada, Australia, Japan, and other countries) to consider it safe, given that most of their toxicity studies return little risk of adverse reactions as well .

The Uses of DROMETRIZOLE TRISILOXANE

drometrizole trisiloxane is a uV absorber/uV filter, it provides uVBand some uVA-spectrum protection.

The Uses of DROMETRIZOLE TRISILOXANE

Drometrizole Trisiloxane is used in the synthesis of UV light absorbers and filters for polyester fibers and suncare formulations.

Background

Drometrizole trisiloxane is a photostable UVA and UVB light filter . The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and Japan, among other countries.
Despite being used elsewhere in the world with relatively few reports of adverse reactions, the FDA continues to cite that the existing scientific record is not sufficient to establish the compound as being generally recognized as safe and effective for over-the-counter sunscreen use .

Indications

Drometrizole trisiloxane is used as an active ingredient in various sunscreens for the indication of protecting the skin by absorbing the damaging UV radiation of sunlight .

Pharmacokinetics

As an active ingredient in sunscreen products, drometrizole trisiloxane is applied directly onto human skin where it acts as a chemical sunscreen layer between skin and sunlight that also directly absorbs the UV sunlight radiation . Since drometrizole trisiloxane is also considered to have little to no absorption through the skin , little systemic exposure and pharmacokinetics are expected and users can freely wash off and re-apply the compound as necessary.

Metabolism

Drometrizole trisiloxane is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.