Chloromethyltrimethylsilane
Synonym(s):(Chloromethyl)trimethylsilane;(Trimethylsilyl)methyl chloride;Silane CMM3;Trimethylsilylchloromethane
- CAS NO.：2344-80-1
- Empirical Formula: C4H11ClSi
- Molecular Weight: 122.67
- MDL number: MFCD00000878
- EINECS: 219-058-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:44
What is Chloromethyltrimethylsilane?
Description
Chloromethyltrimethylsilane is a chemical compound belonging to the trifluoroacetic acid group. It is an essential synthetic intermediate in organic chemistry, used to prepare many types of compounds, including pharmaceuticals, agrochemicals, and dyes. The molecule consists of three silanes linked together by methylene bridges. The synthesis of Chloromethyltrimethylsilane involves reacting a mixture of hydrochloric acid and trifluoroacetic acid with methyl ketones in the presence of ethylene diamine and particles.
Chemical properties
CLEAR COLOURLESS LIQUID
The Uses of Chloromethyltrimethylsilane
(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.
The Uses of Chloromethyltrimethylsilane
(Chloromethyl)trimethylsilane can be treated with aldehydes or ketones in the presence of triphenylphosphine to synthesize terminal alkenes. It can also be used in the preparation of a reagent, trimethylsilylmethyl magnesium chloride, commonly used in Peterson methylenation.
Properties of Chloromethyltrimethylsilane
| Melting point: | <0°C |
| Boiling point: | 98-99 °C(lit.) |
| Density | 0.88 g/mL at 20 °C |
| vapor pressure | ~25 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 27 °F |
| storage temp. | Store below +30°C. |
| solubility | soluble in Benzene, Methanol |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 0.879 |
| Water Solubility | insoluble |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 906705 |
| CAS DataBase Reference | 2344-80-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Silane, (chloromethyl)trimethyl-(2344-80-1) |
| EPA Substance Registry System | Silane, (chloromethyl)trimethyl- (2344-80-1) |
Safety information for Chloromethyltrimethylsilane
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Chloromethyltrimethylsilane
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