Dolutegravir Impurity 3
- CAS NO.：1973402-05-9
- Empirical Formula: C20H19F2N3O5
- Molecular Weight: 419.38
- Update Date: 2025-07-04 15:18:38
What is Dolutegravir Impurity 3?
The Uses of Dolutegravir Impurity 3
(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Properties of Dolutegravir Impurity 3
| Melting point: | 95-100°C |
| Boiling point: | 662.3±55.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.50±1.00(Predicted) |
| color | Yellow |
Safety information for Dolutegravir Impurity 3
Computed Descriptors for Dolutegravir Impurity 3
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Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid METHANE-D3-SULFONYL CHLORIDE N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D TERTIARY BUTANOL-D9 CHLOROFORM-D TOLUENE-D3 Methyl 6-(hydroxymethyl)nicotinate 4-Bromo-3-iodoaniline 2-(4-Bromophenyl)ethylamine 2,6-bis(bromomethyl)pyridine 5-Aminooxazole-4-carbonitrile 4-(piperazin-1-yl)benzene-1,2-diamine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
![(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide](https://img.chemicalbook.in/CAS/20150408/GIF/1335210-35-9.gif)
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