DMT-2μ-O-Me-rG(ib) amidite
- CAS NO.：251647-55-9
- Empirical Formula: C47H60N7O10P
- Molecular Weight: 913.99
- MDL number: MFCD00792625
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:23
What is DMT-2μ-O-Me-rG(ib) amidite?
Description
Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2μ-O-Me-rG(ib) amidite, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.
The Uses of DMT-2μ-O-Me-rG(ib) amidite
5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.
Storage
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Properties of DMT-2μ-O-Me-rG(ib) amidite
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 250 mg/mL (273.53 mM; Need ultrasonic) |
| form | Powder |
| pka | 9.16±0.20(Predicted) |
| color | White to Off-white |
Safety information for DMT-2μ-O-Me-rG(ib) amidite
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for DMT-2μ-O-Me-rG(ib) amidite
| InChIKey | LADCDGNEBIQAAU-KEFUZROQNA-N |
DMT-2μ-O-Me-rG(ib) amidite manufacturer
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product: 251647-55-9 98%
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