DMT-2μ-O-Me-rG(ib) amidite

CAS NO.：251647-55-9
Empirical Formula: C47H60N7O10P
Molecular Weight: 913.99
MDL number: MFCD00792625
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-30 15:13:52

What is DMT-2μ-O-Me-rG(ib) amidite?

Description

Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2μ-O-Me-rG(ib) amidite, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.

The Uses of DMT-2μ-O-Me-rG(ib) amidite

5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.

Storage

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Properties of DMT-2μ-O-Me-rG(ib) amidite

storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (273.53 mM; Need ultrasonic)
form	Powder
pka	9.16±0.20(Predicted)
color	White to Off-white

Safety information for DMT-2μ-O-Me-rG(ib) amidite

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.