2'-OMe-ibu-G Phosphoramidite
Synonym(s):DMT-2′-O-Me-rG(ib) amidite;N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-guanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- CAS NO.：150780-67-9
- Empirical Formula: C45H56N7O9P
- Molecular Weight: 869.94
- MDL number: MFCD16876397
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:27
What is 2'-OMe-ibu-G Phosphoramidite?
The Uses of 2'-OMe-ibu-G Phosphoramidite
2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand.
Definition
2'-OMe-G(iBu)-3'-phosphoramidite is a chemically unstable and heat-sensitive nucleoside phosphoramidite that serves as a foundational element in oligonucleotide synthesis. 2'-OMe-RNA CE (β-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides.
Properties of 2'-OMe-ibu-G Phosphoramidite
| Melting point: | 138 - 140°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | powder |
| pka | 9.16±0.20(Predicted) |
| color | white to off-white |
Safety information for 2'-OMe-ibu-G Phosphoramidite
Computed Descriptors for 2'-OMe-ibu-G Phosphoramidite
| InChIKey | IRRDHRZUOZNWDJ-MLLDKZSOSA-N |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,47,r| |
2'-OMe-ibu-G Phosphoramidite manufacturer
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