Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

CAS NO.：20324-87-2
Empirical Formula: C21H17N2NaO9S2
Molecular Weight: 528.48
MDL number: MFCD00068249
EINECS: 243-735-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-21 16:49:52

What is Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)?

The Uses of Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

AMI-1 is a Histone Methyltransferase (HMT) inhibitor.

What are the applications of Application

AMI-1, sodium salt is a PRMT and HIV-1 RT polymerase inhibitor

Biological Activity

potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).

Properties of Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
form	Brown solid.
color	Light brown to brown
EPA Substance Registry System	2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)

Safety information for Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Computed Descriptors for Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

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