DIMETHYLPHOSPHINE OXIDE

Description

Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.

Chemical properties

Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.

The Uses of DIMETHYLPHOSPHINE OXIDE

Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer.

Reactions

Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.

References

https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en&region=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.