Dimethylphosphine oxide
- CAS NO.：7211-39-4
- Empirical Formula: C2H7OP
- Molecular Weight: 78.05
- MDL number: MFCD02824571
- EINECS: 230-591-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-10-09 21:41:12
What is Dimethylphosphine oxide?
Description
Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.
Chemical properties
Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.
The Uses of Dimethylphosphine oxide
Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer.
Reactions
Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.
References
https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en®ion=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.
Properties of Dimethylphosphine oxide
| Boiling point: | 65-67 °C(Press: 6 Torr) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | liquid |
| color | white solid to light yellow |
| Sensitive | air sensitive |
| InChI | InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3 |
Safety information for Dimethylphosphine oxide
Computed Descriptors for Dimethylphosphine oxide
| InChIKey | HGDIHUZVQPKSMO-UHFFFAOYSA-N |
| SMILES | P(=O)(C)C |
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