Dimethylenastron
Synonym(s):2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone;7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione;Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem
- CAS NO.：863774-58-7
- Empirical Formula: C16H18N2O2S
- Molecular Weight: 302.39
- MDL number: MFCD09264157
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:35:11
What is Dimethylenastron?
The Uses of Dimethylenastron
Dimethylnasetron is an inhibitor of mitotic motor kinesin Eg5, triggering apoptosis and upregulates Hsp-70 in human myeloma cells.
What are the applications of Application
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound
Biochem/physiol Actions
Dimethylenastron is specific, reversible inhibitor of the mitotic motor kinesin Eg5. Dimethylenastron inhibits bipolar spindle formation, and inhibits proliferation, migration and invasion of several pancreatic cancer cell lines in cell based assays.
Storage
Store at -20°C
Properties of Dimethylenastron
| Boiling point: | 475.6±55.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 9.59±0.10(Predicted) |
| form | powder |
| color | white to beige |
Safety information for Dimethylenastron
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H360:Reproductive toxicity H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. |
Computed Descriptors for Dimethylenastron
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