dihydrolycorine
- CAS NO.：6271-21-2
- Empirical Formula: C16H19NO4
- Molecular Weight: 289.33
- MDL number: MFCD09953807
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:16:30
What is dihydrolycorine?
Description
Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.
The Uses of dihydrolycorine
Dihydrolycorine is a derivative of Lycorine (L487550), the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Properties of dihydrolycorine
| Melting point: | 247 °C |
| Boiling point: | 460.5±45.0 °C(Predicted) |
| Density | 1.48 |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Cryst. |
| pka | 14.13±0.40(Predicted) |
| color | White to off-white |
Safety information for dihydrolycorine
Computed Descriptors for dihydrolycorine
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